- the most frequent bacteria is staphylococcus aureus 
- cartilage damage can occur by 8 hours 
- most commonly affected joints in descending order - knee (~ 50% of cases) > 
- hip > 
- shoulder > 
- elbow > 
- ankle > 
- sternoclavicular joint - found in IV drug users 
- pseudomonas aeruginosa was most common pathogen in 1980's 
- staphylococcus aureus is now the most common pathogen in all patients, including IV drug users 
 
 
- risk factors - age > 80 years 
- medical conditions - diabetes 
- rheumatoid arthritis 
- cirrhosis 
- HIV 
 
- history of crystal arthropathy 
- endocarditis or recent bacteremia 
- IV drug user 
- recent joint surgery 
 
Symptoms
- pain in affected joint 
- fevers (only present in 60% of cases) 
- may appear toxic 
- Inability to bear weight 
- inability to tolerate PROM 
3 etiologies of bacterial seeding of joint
- bacteremia 
- direct inoculation from trauma or surgery 
- contiguous spread from adjacent osteomyelitis 
Blood test :
- WBC >10000 
- ESR >30 
- CRP > 5 
Characteristic findings
- joint fluid appears cloudy or purulent 
- cell count with WBC > 50,000 is considered diagnostic for septic arthritis, however lower counts may still indicate infection - prosthetic joint with WBC >1,100 is considered septic 
 
- gram stains only identifies infective organism 1/3 of time 
- glucose less than 60% of serum leve 
Joint fluid aspirate
- gold standard for treatment and allows directed antibiotic treatment 
- should be analyzed for - cell count with differential 
- gram stain 
- culture 
- glucose level 
- crystal analysis - septic arthritis occurs concurrently with gout or pseudogout in < 5% of cases 
 
 
- Differential diagnosis 
- Crystal arthropathy - gout 
- pseudogout 
 
- Cellulitis 
- Bursitis 
treatment: ATB + lavage
 
             
            